Mounjaro drug interactions
Mounjaro · tirzepatide · by Eli Lilly
Interaction lookup
Search by medication name or drug class to see clinically meaningful Mounjaro interactions.
Insulin
ModerateClass: insulin
Hypoglycemia risk when combined; insulin dose typically reduced.
Sulfonylureas
ModerateClass: sulfonylurea
Hypoglycemia risk; sulfonylurea dose typically reduced.
Oral contraceptives
ModerateClass: estrogen / progestin
Delayed contraceptive absorption — barrier method during titration.
Editorial table from FDA labels + drug compendia. Not exhaustive. Discuss any concurrent medication, supplement, or condition with your prescriber before starting or stopping treatment.
Where to get Mounjaro
Ro
from $145/mo- Best for insured patients
- Best for clinical oversight
Ro Body — branded GLP-1 weight care program
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People also ask
Frequently asked
What medications interact with Mounjaro?+
Same tirzepatide interaction profile as Zepbound. Most clinically meaningful: insulin and sulfonylureas (hypoglycemia risk when combined — typical T2D regimen requires dose adjustment), oral contraceptives (delayed absorption — manufacturer recommends non-oral or barrier method for 4 weeks after each dose escalation), warfarin (closer INR monitoring during titration). No major interactions with statins, antihypertensives, or thyroid medications at standard doses.
Can I take Mounjaro with metformin?+
Mounjaro and metformin are commonly co-prescribed without major interaction concerns. GI side effects may be additive in some patients.