Lilly direct-selling Zepbound at $499/mo — compare with 11 other programs
← Hub guides

Therapy & Depression

Mental health telehealth: what to expect

Mental health telehealth is the most-studied form of telemedicine. Outcomes are equivalent to in-person for mild-to-moderate depression and anxiety. The question is which program fits your situation — therapy alone, medication alone, both, or none of the above (a primary-care visit might be the answer).

Therapy vs medication

For mild-to-moderate depression and anxiety: therapy alone, medication alone, and combined all have comparable outcomes at 12 weeks in trials. Combined wins on long-term relapse prevention. Therapy is better for people who can't tolerate side effects. Medication is better for people who can't get reliable weekly therapy time.

SSRI/SNRI basics

First-line antidepressants are SSRIs (sertraline, escitalopram, fluoxetine) — 4-6 weeks to full effect, side-effect profile varies by drug, generics are $10-15/month. SNRIs (duloxetine, venlafaxine) are second-line, often used when SSRIs don't work or when chronic pain coexists.

Async vs sync programs

Async programs (text-based) handle medication management well. Sync (video) is required for therapy and recommended for new diagnoses. Most telehealth mental-health brands offer both tiers; the medication-only tier runs $40-100/month, the medication+therapy tier $200-400/month.

When to skip telehealth

Active suicidal ideation, psychosis, bipolar disorder requiring mood stabilizers, controlled-substance management (most controlled meds aren't telehealth-prescribable in most states post-2025), or pediatric psychiatry — these need in-person care.

Top therapy & depression programs we cover

We may earn a commission when you click links to partners. Affiliate disclosure.