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Avodart drug interactions

Avodart · dutasteride · by GlaxoSmithKline (Avodart)

Reviewed by the glpzoom Editorial Team against primary clinical sources — FDA labeling, peer-reviewed trials, and specialty-society guidelines.
Content current as of June 2026; updated when guidance or availability changes.
Dutasteride has a similar interaction profile to finasteride (both 5-alpha-reductase inhibitors). Reduces PSA by approximately 50% — flag to any prostate cancer screening. Caution with CYP3A4 inhibitors (ketoconazole, ritonavir — can elevate dutasteride blood levels). No major interactions with cardiovascular medications.

Interaction lookup

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  • Saw palmetto

    Minor

    Class: supplement

    Same theoretical additive effect; disclose.

  • PSA tests

    Moderate

    Class: lab interaction

    Reduces PSA by ~50% — same correction factor as finasteride.

Editorial table from FDA labels + drug compendia. Not exhaustive. Discuss any concurrent medication, supplement, or condition with your prescriber before starting or stopping treatment.

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Frequently asked

What medications interact with Avodart?+

Dutasteride has a similar interaction profile to finasteride (both 5-alpha-reductase inhibitors). Reduces PSA by approximately 50% — flag to any prostate cancer screening. Caution with CYP3A4 inhibitors (ketoconazole, ritonavir — can elevate dutasteride blood levels). No major interactions with cardiovascular medications.

Can I take Avodart with metformin?+

Avodart and metformin are commonly co-prescribed without major interaction concerns. GI side effects may be additive in some patients.

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