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Finasteride (Propecia) drug interactions

Finasteride (Propecia) · finasteride · by Multiple (Merck originated as Propecia)

Reviewed by the glpzoom Editorial Team against primary clinical sources — FDA labeling, peer-reviewed trials, and specialty-society guidelines.
Content current as of June 2026; updated when guidance or availability changes.
Finasteride has few clinically significant drug interactions. Can reduce PSA (prostate-specific antigen) levels by approximately 50%, which is important to flag to any doctor running prostate cancer screening — labs need to multiply PSA by 2 for accurate interpretation. No major interactions with statins, antihypertensives, or common cardiovascular drugs.

Interaction lookup

Search by medication name or drug class to see clinically meaningful Finasteride (Propecia) interactions.

  • Saw palmetto

    Minor

    Class: supplement

    Theoretical additive 5-ARI effect; no documented harm but disclose to prescriber.

  • PSA tests

    Moderate

    Class: lab interaction

    Reduces PSA by ~50%. Tell screening providers to multiply by 2 for accurate prostate-cancer interpretation.

Editorial table from FDA labels + drug compendia. Not exhaustive. Discuss any concurrent medication, supplement, or condition with your prescriber before starting or stopping treatment.

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Frequently asked

What medications interact with Finasteride (Propecia)?+

Finasteride has few clinically significant drug interactions. Can reduce PSA (prostate-specific antigen) levels by approximately 50%, which is important to flag to any doctor running prostate cancer screening — labs need to multiply PSA by 2 for accurate interpretation. No major interactions with statins, antihypertensives, or common cardiovascular drugs.

Can I take Finasteride (Propecia) with metformin?+

Finasteride (Propecia) and metformin are commonly co-prescribed without major interaction concerns. GI side effects may be additive in some patients.

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