Ozempic drug interactions
Ozempic · semaglutide · by Novo Nordisk
Interaction lookup
Search by medication name or drug class to see clinically meaningful Ozempic interactions.
Insulin
ModerateClass: insulin
Hypoglycemia risk when combined; dose adjustment required.
Sulfonylureas
ModerateClass: sulfonylurea
Hypoglycemia risk; sulfonylurea dose reduction usually needed.
Oral contraceptives
ModerateClass: estrogen / progestin
Delayed gastric emptying — barrier method recommended during titration.
Editorial table from FDA labels + drug compendia. Not exhaustive. Discuss any concurrent medication, supplement, or condition with your prescriber before starting or stopping treatment.
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Ro
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Ro Body — branded GLP-1 weight care program
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People also ask
Frequently asked
What medications interact with Ozempic?+
Same interaction profile as Wegovy (same active ingredient). Most clinically meaningful: insulin and sulfonylureas (combined hypoglycemia risk — clinicians often reduce these when starting Ozempic), warfarin (monitor INR), oral contraceptives (effectiveness may reduce in patients with severe GI symptoms). Ozempic does not interact with metformin, statins, antihypertensives, or thyroid hormone at standard doses. Insulin co-administration is common in T2D regimens — dose adjustments are standard practice.
Can I take Ozempic with metformin?+
Ozempic and metformin are commonly co-prescribed without major interaction concerns. GI side effects may be additive in some patients.