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Wegovy drug interactions

Wegovy · semaglutide · by Novo Nordisk

Reviewed by the glpzoom Editorial Team against primary clinical sources — FDA labeling, peer-reviewed trials, and specialty-society guidelines.
Content current as of June 2026; updated when guidance or availability changes.
Wegovy slows gastric emptying, which can affect absorption of oral medications taken at the same time. Most clinically meaningful interactions: insulin and sulfonylureas (increased hypoglycemia risk when combined; clinicians often reduce these), warfarin (monitor INR more closely during titration), and oral contraceptives (some evidence of reduced effectiveness in patients with severe GI symptoms; use backup method or non-oral contraception). Wegovy does not interact with most antihypertensives, statins, or thyroid hormone at standard doses. Disclose all medications, supplements, and recent vaccines to your prescriber.

Interaction lookup

Search by medication name or drug class to see clinically meaningful Wegovy interactions.

  • Insulin

    Moderate

    Class: insulin

    Hypoglycemia risk when combined; dose adjustment may be required.

  • Sulfonylureas (glipizide, glimepiride)

    Moderate

    Class: sulfonylurea

    Hypoglycemia risk; typically requires sulfonylurea dose reduction.

  • Oral contraceptives

    Moderate

    Class: estrogen / progestin

    Delayed gastric emptying may reduce contraceptive absorption. Manufacturer recommends barrier method for 4 weeks after each dose escalation.

  • Warfarin

    Moderate

    Class: anticoagulant

    Closer INR monitoring during titration; semaglutide may alter warfarin pharmacokinetics.

  • Levothyroxine

    Minor

    Class: thyroid hormone

    Delayed absorption possible; take levothyroxine on empty stomach as usual; routine TSH monitoring continues unchanged.

Editorial table from FDA labels + drug compendia. Not exhaustive. Discuss any concurrent medication, supplement, or condition with your prescriber before starting or stopping treatment.

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More on Wegovy

People also ask

Frequently asked

What medications interact with Wegovy?+

Wegovy slows gastric emptying, which can affect absorption of oral medications taken at the same time. Most clinically meaningful interactions: insulin and sulfonylureas (increased hypoglycemia risk when combined; clinicians often reduce these), warfarin (monitor INR more closely during titration), and oral contraceptives (some evidence of reduced effectiveness in patients with severe GI symptoms; use backup method or non-oral contraception). Wegovy does not interact with most antihypertensives, statins, or thyroid hormone at standard doses. Disclose all medications, supplements, and recent vaccines to your prescriber.

Can I take Wegovy with metformin?+

Wegovy and metformin are commonly co-prescribed without major interaction concerns. GI side effects may be additive in some patients.

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