How long does it take Wegovy to work?
Reviewed by the glpzoom Editorial Team against primary clinical sources — FDA labeling, peer-reviewed trials, and specialty-society guidelines.
Content current as of June 2026; updated when guidance or availability changes.
Wegovy follows a predictable timeline. Appetite suppression often starts within the first 1-2 weeks (during initial 0.25mg titration). Visible scale weight loss typically becomes evident at 4-8 weeks. Meaningful clinical weight loss (5% of body weight) is usually reached by month 3-4. Maximum efficacy comes at the 2.4mg maintenance dose, typically reached at week 16-17. Mean weight loss in the STEP-1 trial was 14.9% at 68 weeks. Individual variation is wide: top responders see 20%+, bottom-tier see <5%. Plateau typically begins around month 9-12 as the body defends its new weight set point. If you haven't seen any weight loss by month 4 at the highest tolerated dose, discuss with your prescriber about switching or escalation.
Where to start
Licensed US telehealth services that handle this. We may earn a commission when you sign up. See disclosure.
Ro
from $145/mo- Best for insured patients
- Best for clinical oversight
Ro Body — branded GLP-1 weight care program
Hims
from $199/mo- Best for cash-pay
- Best for speed
Hims Weight Loss — compounded GLP-1 from $199/mo
Noom Med
from $179/mo- Best for coaching
- Best for maintenance
Noom Med — GLP-1 + behavioral psychology coaching