Lilly direct-selling Zepbound at $499/mo — compare with 11 other programs →
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How much does Zepbound cost?

Reviewed by the glpzoom Editorial Team against primary clinical sources — FDA labeling, peer-reviewed trials, and specialty-society guidelines.
Content current as of June 2026; updated when guidance or availability changes.
Zepbound's list price is roughly $1,060 per 28-day supply at retail pharmacies. Eli Lilly runs LillyDirect Self-Pay, which offers vials at $349-$549/month depending on dose for eligible self-pay patients. Pen injectors are not part of the discounted self-pay program — only the single-dose vials. Commercial insurance coverage exists but typically requires prior authorization and meeting BMI thresholds. Lilly's commercial savings card can bring eligible commercial-insured patients to as low as $25/month for the first 6 months, then up to $150/month for the next 6.

Where to start

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Drugs referenced

Related questions

  • Is Wegovy or Zepbound cheaper?

    At list price, Zepbound is slightly cheaper than Wegovy (~$1,060 vs ~$1,349/month). For cash-pay patients, Lilly's self-pay vial program ($349-$549/month for Zepbound) tends to undercut Novo's NovoCare self-pay program ($499/month for Wegovy) at lower doses. At higher Zepbound doses, the gap narrows. Insurance coverage patterns are similar; the better choice

  • Does insurance cover Zepbound?

    Like Wegovy, Zepbound coverage depends on your plan. Many commercial plans require BMI ≥30 (or ≥27 with a comorbidity) and prior authorization. Medicare does not cover Zepbound for weight loss, though it does cover Mounjaro (same active ingredient) for type 2 diabetes. Medicaid coverage varies by state. The Lilly commercial savings card can layer on top of i

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