Lilly sells Zepbound vials from $299/mo: compare 11 direct-pay programs →
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How much does Zepbound cost?

Reviewed by the WeighedHealth Editorial Team against primary clinical sources — FDA labeling, peer-reviewed trials, and specialty-society guidelines.
Content current as of July 2026; updated when guidance or availability changes.
Zepbound's list price is roughly $1,060 per 28-day supply at retail pharmacies. Eli Lilly runs LillyDirect Self-Pay, which offers vials at $299 (2.5 mg), $399 (5 mg), and $449 (7.5-15 mg) per month when refilled within 45 days, or $499-$699 for 7.5-15 mg otherwise. The Zepbound savings card applies to the single-dose pen instead. Commercial insurance coverage exists but typically requires prior authorization and meeting BMI thresholds. Lilly's savings card for the single-dose pen can bring eligible commercially insured patients to $25/month, with savings capped at $100/month and $1,300/year, through December 31, 2026.

Where to start

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Drugs referenced

Related questions

  • Is Wegovy or Zepbound cheaper?

    At list price, Zepbound is slightly cheaper than Wegovy (~$1,060 vs ~$1,349/month). For cash-pay patients, Lilly's self-pay vials ($299-$449/month for Zepbound when refilled within 45 days) compare with Novo's NovoCare self-pay ($349/month for Wegovy pens). The 2.5 mg Zepbound vial is cheaper; from 5 mg up the vials cost more than Wegovy self-pay. Insurance

  • Does insurance cover Zepbound?

    Like Wegovy, Zepbound coverage depends on your plan. Many commercial plans require BMI ≥30 (or ≥27 with a comorbidity) and prior authorization. Medicare does not cover Zepbound for weight loss, though it does cover Mounjaro (same active ingredient) for type 2 diabetes. Medicaid coverage varies by state. The Lilly commercial savings card can layer on top of i

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