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How much weight can you lose on Wegovy?

Reviewed by the glpzoom Editorial Team against primary clinical sources — FDA labeling, peer-reviewed trials, and specialty-society guidelines.
Content current as of June 2026; updated when guidance or availability changes.
In the STEP-1 trial, adults on Wegovy 2.4mg weekly plus lifestyle changes lost approximately 15% of body weight on average over 68 weeks, vs ~2.4% in the placebo group. About one-third of patients lost ≥20%. Real-world outcomes are typically somewhat lower than trial results because adherence, dose escalation pace, and lifestyle support vary. Most patients see the steepest weight loss in months 3-9 once they reach maintenance dose, with the curve flattening as the body adapts. Discontinuation typically results in weight regain; Wegovy is intended as long-term therapy.

Where to start

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Drugs referenced

Related questions

  • How do GLP-1 drugs work?

    GLP-1 receptor agonists mimic glucagon-like peptide-1, a gut hormone released after eating. They work through three main pathways: (1) Slowing gastric emptying — food stays in the stomach longer, prolonging fullness. (2) Suppressing appetite in the brain — they reduce the constant 'food noise' many patients describe, making it easier to eat smaller portions

  • What happens when you stop taking Wegovy?

    Wegovy is approved for chronic weight management — meaning it's intended as long-term therapy, not a short course. In the STEP-4 extension trial, patients who stopped Wegovy after a year of treatment regained approximately 67% of their lost weight within a year off the drug, even with continued lifestyle support. The mechanism (appetite suppression) reverses

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