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What are the most common Wegovy side effects?

Reviewed by the glpzoom Editorial Team against primary clinical sources — FDA labeling, peer-reviewed trials, and specialty-society guidelines.
Content current as of June 2026; updated when guidance or availability changes.
The most common Wegovy side effects are gastrointestinal: nausea (40-44% of trial patients), diarrhea (30%), vomiting (24%), and constipation (24%). These typically peak during dose escalation in the first 4-8 weeks and improve as the body adapts. Less common but serious risks include gallbladder problems, pancreatitis, kidney strain (especially if dehydrated), and worsening of diabetic retinopathy in patients with diabetes. Wegovy carries a black-box warning for medullary thyroid carcinoma risk based on rodent studies; the risk in humans is not established but the drug is contraindicated in patients with personal or family history of MTC or MEN2.

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Drugs referenced

Related questions

  • How long do Wegovy side effects last?

    Most patients experience the worst nausea and GI side effects in the first 4-8 weeks of starting Wegovy and each time the dose increases. The body adapts and side effects typically decrease meaningfully by week 12-16 on a stable dose. Strategies that help: smaller meals, lower-fat foods, hydration, and slowing the titration schedule if needed (your clinician

  • Do Wegovy and Zepbound have the same side effects?

    Wegovy (semaglutide) and Zepbound (tirzepatide) share very similar side-effect profiles: nausea, constipation, diarrhea, vomiting, and fatigue, all most pronounced during dose escalation. Some patients report Zepbound nausea as stronger at equivalent weight-loss-effectiveness doses; others find Zepbound easier to tolerate. Both carry the same black-box warni

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