How do GLP-1 drugs work?

GLP-1 receptor agonists mimic glucagon-like peptide-1, a gut hormone released after eating. They work through three main pathways: (1) Slowing gastric emptying — food stays in the stomach longer, prolonging fullness. (2) Suppressing appetite in the brain — they reduce the constant 'food noise' many patients describe, making it easier to eat smaller portions

Is Wegovy or Zepbound cheaper?

At list price, Zepbound is slightly cheaper than Wegovy (~$1,060 vs ~$1,349/month). For cash-pay patients, Lilly's self-pay vials ($299-$449/month for Zepbound when refilled within 45 days) compare with Novo's NovoCare self-pay ($349/month for Wegovy pens). The 2.5 mg Zepbound vial is cheaper; from 5 mg up the vials cost more than Wegovy self-pay. Insurance

Wegovy vs Zepbound: which is more effective?

Reviewed by the WeighedHealth Editorial Team against primary clinical sources — FDA labeling, peer-reviewed trials, and specialty-society guidelines.

Content current as of July 2026; updated when guidance or availability changes.

In separate Phase 3 trials, Zepbound (tirzepatide 15mg) produced ~20% mean body weight loss vs Wegovy (semaglutide 2.4mg) at ~15%. A head-to-head trial (SURMOUNT-5) confirmed Zepbound's edge. That said, individual response varies widely: some patients lose more on semaglutide than tirzepatide, others tolerate one's side-effect profile better than the other. Cost, insurance formulary, and dose-titration tolerability often decide which drug a patient ends up on. Both are administered as once-weekly subcutaneous injections with similar titration schedules.

Where to start

Licensed US telehealth services that handle this. We may earn a commission when you sign up. See disclosure.

Ro
from $149/mo
- Best for insured patients
- Best for clinical oversight
Ro Body, branded GLP-1 weight care program
Visit Ro →Read review
Hims
from $149/mo
- Best for cash-pay
- Best for speed
Hims Weight Loss, branded GLP-1 on a monthly membership
Visit Hims →Read review

Wegovy vs Zepbound: which is more effective?

Where to start

Ro

Hims

Drugs referenced

Related questions