Aldactone drug interactions
Aldactone · spironolactone · by Multiple
Interaction lookup
Search by medication name or drug class to see clinically meaningful Aldactone interactions.
Potassium supplements
ModerateClass: potassium
Hyperkalemia risk; avoid combination or monitor potassium closely.
ACE inhibitors / ARBs
ModerateClass: RAAS blocker
Additive hyperkalemia risk; periodic potassium monitoring.
NSAIDs (long-term)
ModerateClass: NSAID
Reduced diuretic effect + kidney function risk; consider acetaminophen if possible.
Editorial table from FDA labels + drug compendia. Not exhaustive. Discuss any concurrent medication, supplement, or condition with your prescriber before starting or stopping treatment.
Where to get Aldactone
Curology
from $20/moCurology — prescription-strength formula made for your skin
Apostrophe
from $20/moApostrophe — board-certified dermatologists prescribe online
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Frequently asked
What medications interact with Aldactone?+
Most clinically significant: potassium-sparing effect — avoid combining with potassium supplements, ACE inhibitors, ARBs, or other potassium-sparing diuretics (hyperkalemia risk). Some patients on lithium need closer monitoring. May increase digoxin levels. Disclose all medications and check periodic potassium labs.
Can I take Aldactone with metformin?+
Aldactone and metformin are commonly co-prescribed without major interaction concerns. GI side effects may be additive in some patients.