Lilly direct-selling Zepbound at $499/mo — compare with 11 other programs
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Cheapest weight loss programs

Sorted by lowest monthly starting price. Cheaper isn't always better, read each program's fit notes.

Written by

WeighedHealth Editorial Team

Editorial team-reviewed

Against primary clinical sources
Last reviewed July 2026
  1. #1
    HealthRX logo

    HealthRXTop pick

    HealthRX: low-cost compounded GLP-1

    From

    $99/mo

    Clinical model
    Pricing
    Availability
    Cancellation
    Experience
  2. #2
    Ro logo

    Ro

    Ro Body — branded GLP-1 weight care program

    From

    $145/mo

    Clinical model
    Pricing
    Availability
    Cancellation
    Experience
  3. #3
    Hims logo

    Hims

    Hims Weight Loss — compounded GLP-1 from $199/mo

    From

    $199/mo

    Clinical model
    Pricing
    Availability
    Cancellation
    Experience

How we rank

We never accept payment for placement. Rankings reflect public pricing, user ratings, and editorial judgment using the same five-factor framework on every program: clinical model, pricing transparency, state availability, cancellation terms, customer experience. When we earn affiliate commission, it does not change a brand's position. Read our full disclosure.

How to vet any weight loss telehealth program

Before you pay, get a clear answer to each of these. If a provider makes any of them hard to find, that is itself an answer.

  • Total all-in cost. Platform or membership fee plus medication plus shipping — the real monthly number, not the teaser. And is it the same at every dose, or does it climb as you titrate up?
  • Brand-name vs compounded. An FDA-approved finished drug (Wegovy, Zepbound), or a pharmacy-compounded formulation that is not FDA-approved? After the 2026 shortage resolution, compounded GLP-1s are restricted to documented individual need.
  • Named pharmacy + certification. Does it name its dispensing or 503A pharmacy and hold LegitScript certification? Their absence is a flag, not proof of a problem.
  • A real prescriber. A licensed, board-certified clinician doing an individual evaluation — not an automated approval that promises medication before anyone reviews your health.
  • Cancellation + commitment. Month-to-month, or locked into a 3, 6, or 12-month plan? What are the cancellation terms and fees?
  • Honest labeling. Does it clearly state that compounded medication is not FDA-approved and not therapeutically equivalent to the brand? The FTC has fined providers that blurred this.

See what 15 GLP-1 providers actually charge

Platform fee vs medication, honest starting all-in monthly cost, brand-name vs compounded, pharmacy transparency — read from each provider, free to cite.

Pricing dataset →

Best GLP-1 telehealth, by what you need

There is no single best program. The right one depends on cost, coverage, and whether you want the FDA-approved branded drug or a compounded formulation.

Best value

HealthRX

Compounded semaglutide from $99/mo on annual plans, LegitScript-certified, names its 503A pharmacy.

Visit HealthRX

Best flat-rate (no dose creep)

Enhance MD

$212/mo the same at every dose — the price does not climb as you titrate up.

Visit Enhance MD

Best if insurance may cover it

PlushCare

Insurance-first with a $19.99/mo membership and a concierge that runs the prior authorization for brand-name Wegovy or Zepbound.

See it in the pricing table →

Best FDA-approved-only

Form Health

Brand-name medication only (Wegovy, Zepbound, Saxenda) with board-certified obesity-medicine physicians — no compounding.

See it in the pricing table →

Best manufacturer cash-pay

NovoCare / LillyDirect

Buy the branded drug direct: Wegovy from $199/mo intro (NovoCare) or Zepbound vials $299/mo (LillyDirect), no membership.

See it in the pricing table →

Best all-inclusive support

Found

Compounded GLP-1 bundled with a multidisciplinary care team from $99/mo on the annual plan.

See it in the pricing table →

What changed in 2026: the compounding shift

From 2022 to 2024, semaglutide and tirzepatide were in official FDA shortage, which let pharmacies legally compound low-cost versions (often $150–$300/mo). The FDA declared the tirzepatide shortage resolved in late 2024 and semaglutide in early 2025, and the wind-down grace periods ended around mid-2025. In 2026 you generally cannot get a compounded GLP-1 simply because it is cheaper — compounding is now limited to patient-specific prescriptions with a documented medical reason (an allergy to an inactive ingredient, or a dose not commercially available).

That reshaped the market. Big brand-name platforms Ro and Hims exited compounded GLP-1 and now sell only FDA-approved medication. The FDA issued dozens of warning letters (58 in September 2025, more in 2026) to telehealth firms for marketing compounded products as equivalent to the brand, and the FTC fined NextMed for advertising prices that excluded the medication and for fabricated reviews. On April 30, 2026 the FDA proposed permanently barring bulk 503B compounding of semaglutide, tirzepatide, and liraglutide.

The flip side is better branded access: manufacturer direct-pay (NovoCare, LillyDirect) lowered cash prices, and a Medicare GLP-1 Bridge program brings eligible enrollees a lower copay. For a program still marketing compounded GLP-1 as a cheap copy of the brand, ask how it complies with the patient-specific rule. See our compounded-vs-branded legal-status explainer for the full picture.

Project your trial-average outcome

Move the slider to your current weight. The numbers below are trial-average results. Individual outcomes vary widely.

  • Tirzepatide (Zepbound, 15 mg)46 lbs

    20.9% mean body-weight reduction at 72 weeks (SURMOUNT-1)

  • Semaglutide (Wegovy, 2.4 mg)33 lbs

    14.9% mean body-weight reduction at 68 weeks (STEP-1)

  • Placebo + lifestyle alone5 lbs

    2.4% mean body-weight reduction (STEP-1 placebo arm)

Trial averages, not predictions. Real-world outcomes depend on adherence, dose tolerance, diet, exercise, and individual response. ~10% of trial participants did not lose ≥5% body weight; ~30% achieved ≥20%.

Match me to a program →

All 5 programs compared

Sort by price, behavioral layer, or user rating.

Every program in this table is ranked on the same criteria. We earn a commission if you click through to some of them, but ranking and scoring are never sold. Programs that pay us nothing appear on equal footing.

Program
HealthRX

HealthRX: low-cost compounded GLP-1

$99/moVisit →
Ro

Ro Body — branded GLP-1 weight care program

$145/mo2/10Visit →
Hims

Hims Weight Loss — compounded GLP-1 from $199/mo

$199/mo1/10Visit →
Enhance MD

Enhance MD: flat-rate GLP-1 weight-loss care

$212/moVisit →
Oak

Oak weight-loss telehealth program

Visit →

Start from your priority

There's no single best program, only the best one for what you care about most. Pick your priority.

Hidden costs to watch for

The sticker price is rarely the whole bill. Before you enroll, check each of these.

Dose-escalation price jumps
Many programs price the starter dose low, then raise the monthly cost at higher titration steps. Confirm the price at the maintenance dose, not just week 1.
Membership fee on top of medication
Some platforms split the bill: a low medication price plus a separate monthly membership. Add both to get the true monthly cost.
Required lab work
A baseline A1C or metabolic panel may be required and billed separately if not bundled. Ask whether labs are included.
Cancellation friction & lock-ins
Watch for multi-month commitments, auto-renew after an intro month, and cancel-by-phone-only flows. The intro price is not the renewal price.
Shipping & cold-chain fees
Injectable GLP-1s ship cold. Some programs add a shipping or handling fee per order, especially for expedited or summer cold-pack shipping.

How we evaluated

Pricing & availability verified quarterly. Last review cycle: current month.

Programs considered
5

Every active telehealth program in our database for this category.

Made the shortlist
3

Ranked above by the cheapest metric.

What this ranking measures. Sorted by lowest monthly starting price. Cheaper isn't always better, read each program's fit notes.

How we built the candidate list. We track every US-licensed telehealth program that prescribes in this category. We exclude programs that don't serve all 50 states transparently, charge undisclosed re-engagement fees, or require irrevocable contracts. None of these exclusions are subjective. They are documented rules in our full methodology.

What we did not do. We did not clinically evaluate any patient. We did not enroll undercover. Pricing on this page reflects each program's publicly listed rates as of the “last reviewed” date. Insurance acceptance and PA outcomes vary by plan; check with your insurer.

What we did do. Mystery-shopped sign-up flows, compared formularies on each provider's public site, recorded time-to-first-shipment where reported, and confirmed state availability against each program's self-reported coverage map.

The competition

Other weight loss programs we considered. Ranked below the top 3 on this metric.

More weight loss rankings

One monthly digest when rankings or prices shift.