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What supplements should you take on a GLP-1?

Reviewed by the glpzoom Editorial Team against primary clinical sources — FDA labeling, peer-reviewed trials, and specialty-society guidelines.
Content current as of June 2026; updated when guidance or availability changes.
Because GLP-1s sharply reduce how much you eat, the practical supplement question is about preventing gaps, not boosting performance. The highest-value addition for most people is protein — via food first, or a protein shake or powder when appetite makes hitting 80-100g/day hard. Fiber supplements (psyllium) can ease the constipation GLP-1s commonly cause if dietary fiber falls short. A standard multivitamin is reasonable insurance when overall intake drops, and adequate hydration with electrolytes helps with the fatigue and lightheadedness some report during titration. There's no evidence that 'fat-burner' or 'GLP-1 booster' supplements add anything — many are marketing built on the GLP-1 wave, and some contain stimulants that worsen the nausea and heart-rate effects. If you take a GLP-1 for type 2 diabetes, don't add berberine or other glucose-lowering supplements without telling your prescriber, since the combination can cause hypoglycemia. Bottom line: protein, fiber if needed, a basic multivitamin, electrolytes for hydration — skip the proprietary 'GLP-1 support' blends.

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Drugs referenced

Related questions

  • What should you eat on a GLP-1 (and what to avoid)?

    On a GLP-1, eat protein first (80-100g/day to protect muscle), add fiber and extra water, and eat small slow meals. Avoid high-fat and fried foods, large portions, carbonated drinks, alcohol, and refined sugar, all of which worsen nausea on delayed gastric emptying.

  • How should you exercise on a GLP-1?

    On a GLP-1, prioritize resistance training 2-4x/week over cardio to protect the lean muscle that weight loss can erode (20-40% of weight lost can be muscle). Pair it with 80-100g protein daily, stay hydrated, and don't over-train in a steep calorie deficit.

  • What are the most common Wegovy side effects?

    The most common Wegovy side effects are gastrointestinal: nausea (40-44% of trial patients), diarrhea (30%), vomiting (24%), and constipation (24%). These typically peak during dose escalation in the first 4-8 weeks and improve as the body adapts. Less common but serious risks include gallbladder problems, pancreatitis, kidney strain (especially if dehydrate

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