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Cialis tadalafil

pronounced as (ta da' la fil)

FDA-approved forErectile dysfunctionBenign prostatic hyperplasia
ED TreatmentBy Eli Lilly· FDA-approved 2003

Long-acting PDE5 inhibitor. 24-36 hour duration. Daily low-dose option for spontaneity.

Editorial pickHimsfrom $13/moSee if I qualify →
Cialis delivery device illustration
Reviewed by the WeighedHealth Editorial Team against primary clinical sources — FDA labeling, peer-reviewed trials, and specialty-society guidelines.
Content current as of July 2026; updated when guidance or availability changes.

Cialis vs Viagra

Onset vs duration is the real decision. Sildenafil (Viagra) works in 30-60 min for 4-6 hours; tadalafil (Cialis) lasts up to 36 hours for less clock-watching.

CialisViagra
Generic nametadalafilsildenafil
ManufacturerEli LillyPfizer
FDA statusFDA-approved 2003FDA-approved 1998
Clinical efficacy
Pivotal trial
Boxed warningNoNo
Full pageCialisViagra

Deep comparison: Cialis vs Viagra

What is Cialis?

Cialis is the brand-name tadalafil, longer-acting than sildenafil. Generic since 2018. Two dosing modes: as-needed (10-20mg) or daily low-dose (2.5-5mg). The daily mode is popular because it allows spontaneous activity without timing pills.

How does Cialis work?

Same mechanism as sildenafil — PDE5 inhibition. Longer half-life (17.5 hours vs 4 hours for sildenafil) means effect lasts longer per dose.

Who can take Cialis?

Adult men with ED. Daily low-dose also FDA-approved for benign prostatic hyperplasia (BPH). Same contraindications as sildenafil (nitrates, alpha-blockers, etc.).

How is Cialis taken?

As-needed: 10-20mg before sexual activity. Daily: 2.5-5mg every day at the same time.

Cialis — time profile
01.5 days
Onset
30 min
Peak
2h
Effective until
1.5 days

How much does Cialis cost?

Generic tadalafil $1-8/tablet. Telehealth $30-100/month depending on dose and as-needed vs daily.

What side effects can Cialis cause?

Back pain, muscle aches (more common than with sildenafil). Headache, flushing, nasal congestion. Same vision/hearing warnings.

What if I miss a dose of Cialis?

Daily Cialis: if missed, take when remembered if within 12 hours; if longer, skip and resume regular schedule. Do not double up. As-needed Cialis: no missed-dose concept; take 30 minutes before activity, max one dose per 24 hours.

Where to get Cialis

Licensed US telehealth providers that prescribe/ship Cialis. We earn commission when you book. See disclosure.

  • Hims logo

    Hims

    from $13/mo
    • Best for cash-pay
    • Best for speed

    Hims ED — generic sildenafil from $13/mo

    Why we picked it

    Generic sildenafil at roughly half the chewable-competitor per-dose cost, with branded Viagra/Cialis available if you want it.

    Who should skip

    Skip if you want fast-onset chewables — Hims uses standard tablets.

    Off-Rx: no plan
    Flaws but not dealbreakers (2)
    • No chewable format
    • Subscription auto-renews — set a calendar reminder if unsure

    We may earn a commission. Pricing on partner site is final.

  • Ro logo

    Ro

    from $2/mo
    • Best for clinical oversight

    Ro — original online ED brand, sildenafil & tadalafil

    Why we picked it

    Cleaner clinical voice and quarterly auto-ship with reminders means less reorder friction once you've settled on a dose.

    Who should skip

    Skip if you want the lowest entry price — Hims undercuts Ro's starting tier.

    Off-Rx: no plan
    Flaws but not dealbreakers (2)
    • Entry price slightly above Hims
    • No chewable option

    We may earn a commission. Pricing on partner site is final.

Not sure which Cialis program fits?

2 questions, ~60 seconds. We'll match you with three programs and explain the trade-offs.

Start free assessment

No email required. Resume any time.

Preview
Q1

What are you looking for?

  • Lowest price (generic sildenafil)
  • Chewable, no swallowing pills
  • Discreet packaging + delivery
  • Want full doctor consult first

+ 1 more in the full assessment

Ask the urologist

How much does online ED treatment cost?+

Generic sildenafil (the active ingredient in Viagra) through telehealth typically runs $2-7 per dose depending on quantity ordered. Generic tadalafil (the active ingredient in Cialis) is similar, with daily low-dose options around $1-3/day. Branded Viagra and Cialis cost dramatically more — $50-90/pill at retail pharmacies. Most telehealth services include the clinical consultation in the medication price; some charge a small one-time evaluation fee. Insurance coverage for ED medications is patchy — many plans exclude them entirely, especially for cash-pay branded products.

Full answer →
Sildenafil vs tadalafil: which is better?+

Sildenafil and tadalafil are both PDE5 inhibitors with similar efficacy but different pharmacokinetics. Sildenafil onset is 30-60 minutes with a 4-6 hour duration — useful for planned activity. Tadalafil onset is similar but duration is much longer at up to 36 hours, which is why it's marketed as 'the weekend pill.' Tadalafil also has a daily low-dose formulation (2.5-5mg) that maintains continuous effect and is sometimes combined with BPH treatment. Side-effect profiles overlap (headache, facial flushing, indigestion) but tadalafil can cause more muscle aches and sildenafil more visual disturbance. Many patients try both to see which they prefer.

Full answer →
Tadalafil daily vs as-needed: which is better?+

Tadalafil (generic Cialis) comes in two dosing strategies. As-needed dosing (10-20mg) is taken approximately 30 minutes before sexual activity and lasts up to 36 hours — useful for planned activity or spontaneity within a long window. Daily low-dose (2.5-5mg) is taken every day to maintain continuous low blood levels — useful when you don't want to time activity around dosing, or when treating both ED and BPH (benign prostatic hyperplasia). Daily is more expensive cumulatively because you take it every day, but per-pill cost is lower. Side effects are similar between dosing strategies; some patients report less side-effect peak on daily because the blood level is steadier. Daily dosing is also often preferred by patients who want to feel 'ready' without a planning step. The choice is preference-driven — many patients try one and switch if it doesn't fit their pattern.

Full answer →
Does insurance cover ED medication?+

Most commercial insurance plans exclude ED medications from coverage or impose tight restrictions. When ED medications are covered, the typical pattern is: generic sildenafil or tadalafil only (branded Viagra and Cialis rarely covered), with quantity limits (4-8 pills per month), and often only for FDA-approved indications (erectile dysfunction with documented organic cause, BPH for daily tadalafil). Coverage is more common when ED is secondary to a covered condition (post-prostatectomy, diabetes, spinal cord injury) than when it's primary. Medicare Part D plans typically do not cover ED medications. Telehealth services that prescribe generic sildenafil/tadalafil at $2-7/pill cash-pay are often cheaper than navigating insurance restrictions, especially for patients without diabetes-related coverage triggers.

Full answer →
How quickly does Cialis (tadalafil) start working?+

Tadalafil (brand name Cialis) typically begins working within 30 minutes of taking an as-needed dose (10-20mg), with peak blood level around 2 hours after dosing. The clinical effect lasts up to 36 hours — substantially longer than sildenafil's 4-6 hours. Food does not significantly affect tadalafil absorption (unlike sildenafil, which a high-fat meal can slow). The long duration means tadalafil can be taken in the morning for activity later in the day or evening without needing to time precisely. For daily low-dose tadalafil (2.5-5mg), continuous blood levels mean no specific 'onset' — the medication is always active. Side effects (headache, facial flushing, indigestion, muscle aches) typically appear within the same window as the therapeutic effect. As with all PDE5 inhibitors, response requires sexual stimulation — tadalafil does not cause an erection without arousal.

Full answer →
Does tadalafil (Cialis) interact with alcohol?+

Moderate alcohol (1-2 drinks) generally OK with Cialis. 3+ drinks: hypotension risk, headache, palpitations. Heavy drinking also impairs erections. Avoid combination with alpha-blockers.

Full answer →

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Related terms

Related topics

How to get it

  1. Take the eligibility quiz

    5 minutes of medical-history questions matched to the medication's FDA criteria. Free, no commitment.

  2. Submit ID + a recent photo

    Required by every legitimate US telehealth platform to verify identity and meet state prescribing rules.

  3. Async clinical review

    A licensed clinician in your state reviews your history and decides whether the medication is appropriate. Typically within 24-48 hours.

  4. Prescription ships

    If approved, the medication is sent from a partner pharmacy. Initial titration dose arrives in 3-7 days for most US states.

  5. Ongoing support

    Most programs include follow-up check-ins, dose adjustments, and side-effect support. Coverage varies by program.

Sources

Primary references this page draws from. We cite original sources so you can verify any claim.

For clinicians: see the Cialis prescribing summary.

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