Does tadalafil (Cialis) interact with alcohol?
Reviewed by the glpzoom Editorial Team against primary clinical sources — FDA labeling, peer-reviewed trials, and specialty-society guidelines.
Content current as of June 2026; updated when guidance or availability changes.
Tadalafil (Cialis) and moderate alcohol (1-2 drinks) are generally tolerated without significant interaction for most healthy adults. Both can lower blood pressure mildly via vasodilation; combined, the effect is additive but usually within safe limits. The concern is heavier alcohol use: 3+ drinks combined with tadalafil can produce orthostatic hypotension (dizziness on standing, fainting), headache, palpitations. Heavy drinking also impairs erectile function independently — undermining the purpose. Practical rule: 1-2 drinks max if taking tadalafil. Avoid if you also take alpha-blockers or have a history of postural hypotension. Don't combine tadalafil with binge drinking.
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Drugs referenced
Related questions
Does sildenafil (Viagra) interact with alcohol?
1-2 drinks generally OK with Viagra. 3+ drinks: dizziness and impaired erection. Eat first, normal sildenafil timing (30-60 min before). Never combine with nitrates.