Zepbound dosage chart and titration schedule
Zepbound · tirzepatide · by Eli Lilly
Zepbound dosage chart
Once-weekly subcutaneous injection
| When | Dose | Notes |
|---|---|---|
| Weeks 1-4 | 2.5 mg once weekly | Starting dose — titration only |
| Weeks 5-8 | 5 mg once weekly | First maintenance option |
| Weeks 9-12 | 7.5 mg once weekly | Optional step |
| Weeks 13-16 | 10 mg once weekly | Maintenance option |
| Weeks 17-20 | 12.5 mg once weekly | Optional step |
| Week 21 onward | 15 mg once weekly | Maximum dose |
Maintenance: Maintenance is 5 mg, 10 mg, or 15 mg once weekly. Increase in 2.5 mg steps no sooner than every 4 weeks, to the lowest effective dose.
Standard schedule from the FDA Zepbound prescribing information. A prescriber may hold or slow a step for tolerability; do not adjust your dose without clinical guidance.
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People also ask
Frequently asked
What is the standard Zepbound titration schedule?+
Titrated 2.5mg → 5mg → 7.5mg → 10mg → 12.5mg → 15mg, every 4 weeks. Maintenance 5-15mg weekly depending on tolerability and target weight.
What if I miss a Zepbound dose?+
Missed-dose guidance depends on time elapsed since the scheduled injection. As a general rule, take the missed dose within the manufacturer's recovery window; if past that, skip and resume the regular schedule. Confirm with prescribing clinician.