Zepbound drug interactions
Zepbound · tirzepatide · by Eli Lilly
Interaction lookup
Search by medication name or drug class to see clinically meaningful Zepbound interactions.
Insulin
ModerateClass: insulin
Hypoglycemia risk; insulin dose adjustment typical.
Oral contraceptives
ModerateClass: estrogen / progestin
Delayed contraceptive absorption — non-oral or barrier method for 4 weeks after each dose escalation.
Warfarin
ModerateClass: anticoagulant
INR monitoring during titration.
Editorial table from FDA labels + drug compendia. Not exhaustive. Discuss any concurrent medication, supplement, or condition with your prescriber before starting or stopping treatment.
Where to get Zepbound
Ro
from $145/mo- Best for insured patients
- Best for clinical oversight
Ro Body — branded GLP-1 weight care program
Hims
from $199/mo- Best for cash-pay
- Best for speed
Hims Weight Loss — compounded GLP-1 from $199/mo
More on Zepbound
- How much does Zepbound cost?
- Zepbound side effects
- Zepbound dosing and titration schedule
- How does Zepbound work?
- Who qualifies for Zepbound?
- Zepbound and pregnancy: safety, planning, breastfeeding
- Zepbound and alcohol: what to know
- Zepbound missed dose: what to do
- Zepbound savings: coupons, manufacturer programs, lower-cost options
- ← Full Zepbound overview
People also ask
Frequently asked
What medications interact with Zepbound?+
Tirzepatide slows gastric emptying similarly to semaglutide; same caution applies to oral medications taken concurrently. Most clinically meaningful interactions: insulin and sulfonylureas (increased hypoglycemia risk), oral contraceptives (manufacturer recommends switching to non-oral or adding barrier method for 4 weeks after starting and 4 weeks after each dose escalation due to delayed absorption), warfarin (closer INR monitoring). No major interactions with statins, antihypertensives, or levothyroxine at standard doses. Always disclose full medication list to prescriber.
Can I take Zepbound with metformin?+
Zepbound and metformin are commonly co-prescribed without major interaction concerns. GI side effects may be additive in some patients.